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KMID : 1007420140120010037
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Mood and Emotion
2014 Volume.12 No. 1 p.37 ~ p.42
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Initial Response to Medication Predicts Early Improvement after 2 Weeks in Patients with Major Depressive Disorder
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Lee Kyoung-Hwan
Jae Young-Myo
Choi Jin-Hyuk
Jang Sae-Heon
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Abstract
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Background and Objectives : A number of large-scale study and meta-analyses suggested that some current antidepressant treatments can exert some beneficial effect within the first week. With earlier prediction, we can avoid time wasting with unpromising medications and optimize medication for MDD patients. We investigated whether initial clinical change (ICC) and initial subjective response (ISR) can predict early improvement of antidepressant pharmacotherapy.
Materials and Method : The symptoms of depression were assessed on the Hamilton Rating Scale for Depression. ISR was checked by a Korean translation form of the Modified Van Putten and May scale. CGI-I was used to assess ICC. Ratings were made on day 0, 1, 2, 4, 7 and 14. We employed Pearson’s correlation analysis and multivariate logistic regression analyses. Sensitivity, specificity and receiver operating characteristic (ROC) curves were calculated.
Results : Among 33 MDD patients, 72.7% of patients achieved early improvement on HAMD-17. Significant correlation between initial response (ICC or ISR on 4 and 7 day) and early improvement were found. CGI-I score of ≤3 and change in Modified Van Putten and May scale score of ≥9 on day 7 predicted later early improvement.
Conclusion : The findings show that ICC and ISR might be significant predictors of early improvement in MDD pharmacotherapy.
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KEYWORD
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Early improvement, Initial subjective response, Initial clinical change, MDD
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